A biological explanation for the differences in infectivity of geographical isolates of Trichinella

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Abstract
Isolates of Trichinella from Alaska [USA], Canada and Kenya were compared during the intestinal and muscle phases of infection in the A/J mouse. Adults of the 3 isolates occupied similar sites along the intestine but duration in the intestine differed. Histological examination of the small intestine during this period revealed that the inflammatory response of the A/J mouse to infection by the 3 isolates was similar in times of onset. Histological examination of the diaphragm muscle 30 days after infection revealed that the most severe inflammatory response was found around cysts of the Canadian isolate. Results suggest that the differences in infectivity are not related to the host inflammatory response to either intestinal or muscle phase. Isolate infectivity is a function of duration in the small intestine of adult worms or of the fecundity of adult worms.

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