DEPOSITION OF IMMUNE-COMPLEXES IN OVARIAN FOLLICLES OF MICE WITH LUPUS-LIKE SYNDROME

Google Scholar
  • 1 January 1980
    • journal article
    • research article
    • Vol. 99  (3) , 589-601
Abstract
The occurrence of immune deposits in the ovaries of mice with lupus-like syndrome was studied by immunofluorescence, light microscopy and EM. Granular deposits of mouse Ig[immunoglobulin]G and C[complement component]3, and occasionally gp70 and denatured DNA, were in the zona pellucida [ZP] of mature and atretic follicles. Dense deposits of foreign material were seen by light and EM in areas of ZP corresponding to the immune deposits. These lesions, presumably induced by immune complexes, resemble the membranous changes observed in the glomerular basement membrane in some of the same mice. Inflammatory changes of the ovarian follicles were not observed.