A comparison of the effects of IGF‐I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers

Publisher Website
Google Scholar
Abstract
The metabolic and cardiovascular effects of recombinant human IGF‐I were compared to insulin in six normal subjects. Subjects were studied twice and intravenously received an infusion of [6,6‐2H2]glucose (0–480 min) and in random order either IGF‐I 20μg kg‐1 h‐1 (43.7 pmol kg‐1 min‐1) or insulin 0.5 mU kg‐1 min‐1 (3.4 pmol kg‐1 min‐1) with an euglycaemic clamp. One subject was withdrawn following a serious adverse event. During the IGF‐I infusion glucose appearance rate (Ra) decreased from 1.79 ± 0.13 at baseline (150–180 min) to 0.35 ± 0.26 mg kg‐1 min‐1 (P < 0.01) at 360min, and glucose utilization rate (Rd) increased from 1.79 ± 0.28 to 4.17 ± 0.84 mg kg‐1 min‐1 (P < 0.01). There was no change in free fatty acids (FFA) and an increase (percentage change from pre‐infusion mean) in cardiac output + 37.3%± 9% (P < 0.01), heart rate + 13%± 2% (P < 0.01) and stroke volume + 21%± 7% (P < 0.05). During the insulin infusion glucose Ra decreased from 1.89 ± 0.13 to 0.34 ± 0.33 mg kg‐1 min‐1 (P < 0.01) and FFA from 0.546 mmoll‐1 to 0.198 mmoll‐1 (P < 0.01), glucose Rd increased from l.89 ± 0.18 to 5.41 ± l.47mg kg‐1 min‐1 (P < 0.01) and there were no significant changes in the cardiovascular variables.

This publication has 16 references indexed in Scilit: