Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032
- 1 July 1987
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 31 (7) , 1135-1136
- https://doi.org/10.1128/aac.31.7.1135
Abstract
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.This publication has 4 references indexed in Scilit:
- Effect of calcium on in vitro activity of LY146032 against Clostridium difficileAntimicrobial Agents and Chemotherapy, 1987
- Clindamycin-Associated Colitis Due to a Toxin-Producing Species of Clostridium in HamstersThe Journal of Infectious Diseases, 1977
- PROTECTIVE EFFECT OF VANCOMYCIN ON CLINDAMYCIN-INDUCED COLITIS IN HAMSTERS1977