Genetic Screening of Compounds Used in Drug Abuse Treatment I. Naltrexone Hydrochloride
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 1 (2) , 103-135
- https://doi.org/10.3109/01480547809034430
Abstract
Several compounds used clinically in drug abuse therapy were evaluated for genetic activity in a series of in vitro assays. This initial report describes the results for one of these compounds, Naltrexone. Naltrexone is a relatively nontoxic drug antagonist related to Naloxone which appears to be effective in diminishing the euphoria and dependence upon heroin in clinical studies. With the exception of weak nonspecific DNA damage observed in an E. coli DNA repair test and possibly with WI-38 cells as well, Naltrexone did not demonstrate significant potential for the induction of gene mutations or chromosomal aberrations under the conditions of this evaluation.This publication has 12 references indexed in Scilit:
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cellsMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- The induction of translocations in mouse spermatozoa I. Kinetics of dose response with acute X-irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- New developments in mutagenicity screening techniques with yeast.Environmental Health Perspectives, 1973
- Evaluation of chromosome aberration effects of chemicals on mouse germ cells.Environmental Health Perspectives, 1973
- Chromosome methodologies in mutation testing: Report of the Ad Hoc Committee of The Environmental Mutagen Society and The Institute for Medical ResearchToxicology and Applied Pharmacology, 1972
- Measurement of Recessive Lethal Damage Over the Entire Genome and at Two Specific Loci in the ad-3 Region of a Two-Component Heterokaryon of Neurospora crassaPublished by Springer Nature ,1971
- The Detection of Chemical Mutagens with Enteric BacteriaPublished by Springer Nature ,1971
- DNA repair and chromatid anomalies in mammalian cells exposed to 4-nitroquinoline 1-oxideMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970
- The mutagenic activity of ICR-170 in Saccharomyces cerevisiaeMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970