Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)
Open Access
- 15 January 1999
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 442 (2-3) , 138-142
- https://doi.org/10.1016/s0014-5793(98)01644-5
Abstract
The solution structure of the Eps15 homology (EH) domain of a human POB1 (partner of RalBP1) has been determined by uniform 13C/15N labeling and heteronuclear multidimensional nuclear magnetic resonance spectroscopy. The POB1 EH domain consists of two EF‐hand structures, and the second one binds a calcium ion. In the calcium‐bound state, the orientation of the fourth α‐helix relative to the other helices of the POB1 EH domain is slightly different from that of calbindin, and much more different from those of calmodulin and troponin C, on the basis of their atomic coordinates.Keywords
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