THE RENAL EXCRETION AND TUBULAR REABSORPTION OF CITRIC ACID IN RENAL TUBULAR ACIDOSIS

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Abstract
Three patients with renal tubular acidosis (RTA) have been examined during metabolic acidosis and after correction of the acidosis. Citrate (Ci) clearance was decreased in all patients during acidosis and was not normalized after correction of the acidosis. Renal metabolism of Ci was in the normal range except in one patient in whom the metabolism probably was decreased because of impaired renal function. Tubular reabsorption of Ci was increased independent of the degree of acidosis. We suggest this might be due to decreased tubular synthesis and secretion of Ci.