THE BEHAVIOR OF H-Y-ENCOMPATIBLE NEONATAL SKIN GRAFTS IN RATS1

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Abstract
Virgin female rats previously systematically sensitized against H-Y antigen almost invariably rejected male skin isografts of adult origin. When the donor was a neonatal animal, these H-Y-incompatible grafts were often permanently accepted. Such neonatal male skin grafts were frequently able to induce a state of unresponsiveness to subsequent grafts of adult male skin. This ability to induce tolerance was evidently dependent upon the persistence of the neonatal skin graft as it did not occur if the neonatal graft was rejected. The behavior of H-Y-incompatible neonatal skin grafts in rats parellels their behavior in mice.