Neonatal suprachiasmatic nucleus ablation: absence of functional and morphological plasticity.
- 1 December 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (12) , 6243-6246
- https://doi.org/10.1073/pnas.75.12.6243
Abstract
Neonatal ablation of the suprachiasmatic nucleus in the rat has 2 important consequences. First, the direct projection from the retina to the suprachiasmatic nucleus fails to develop and no other retinal projection to any hypothalamic nucleus is formed. Second, circadian rhythms in drinking and spontaneous locomotor activity do not appear in these rats when they are tested as adults, and the females exhibit constant vaginal estrus. The central neural mechanisms responsible for the generation and entrainment of circadian rhythmicity in the rat are not capable of either the functional or morphological plasticity characteristic of other developing neural systems.This publication has 23 references indexed in Scilit:
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