Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy
- 1 March 1996
- journal article
- case report
- Published by American Animal Hospital Association in Journal of the American Animal Hospital Association
- Vol. 32 (2) , 111-117
- https://doi.org/10.5326/15473317-32-2-111
Abstract
A 10-year-old, neutered male cocker spaniel-cross experienced regurgitation, dry retching, and weight loss. A large, mediastinal mass and dilatation of the esophagus were seen on thoracic radiographs. Cytological, histopathological, immunohistochemical, and serological findings were consistent with a lymphoepithelial thymoma and focal, esophageal myasthenia gravis. Surgical removal of the mass resulted in rapid resolution of the megaesophagus and a decrease in serum acetylcholine-receptor antibody concentration. The dog was clinically normal until the thymoma recurred six months postoperatively. Clinical signs, diagnostic evaluation, management, and treatment of a dog with thymoma and megaesophagus are described.Keywords
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