Characteristics of Proteinuria in Endemic Nephropathy

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Abstract
Subjects living in the endemic area of Posavina around Slavonski Brod [Yugoslavia] have a significantly greater incidence of proteinuria (13.6%) than those living under the same conditions in the area [Klakar] where endemic nephropathy has not been observed (5.5%). Following determination of the grade and type of proteinuria, physiologic proteinuria was found in 36% of subjects from the endemic area. In nonphysiologic proteinuria the incidence of tubular proteinuria was 41%. A slight selective glomerular proteinuria was found in 51%, and other types of proteinuria in 8% of subjects. Tubular proteinuria was significantly higher in the endemic area than in the control area. The endemic area subjects with tubular proteinuria excreted significantly greater amounts of .beta.2-microglobulin and light Ig chains.

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