Synthesis of Herpes Simplex Virus DNA in Preparations of Chromatin from Infected Cell Nuclei
- 1 November 1978
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 41 (2) , 427-431
- https://doi.org/10.1099/0022-1317-41-2-427
Abstract
Chromatin prepared from cells infected with Herpes simplex virus type 1 or type 2 can synthesize both virus and cell DNA in vitro. The rate of synthesis is comparable to that of isolated whole nuclei. Incorporation is limited, and both cell and virus DNA synthesis are sensitive to the presence of virus-specific antiserum and phosphonoacetate. In chromatin from cells infected with a phosphonoacetate resistant virus mutant, both types of DNA synthesis are resistant to the presence of the inhibitor.This publication has 4 references indexed in Scilit:
- Cell-free synthesis of herpes simplex virus DNA; structure of the in vitro product and nucleolytic degradationBiochemistry, 1977
- Cell-free synthesis of herpes simplex virus DNA: conditions for optimal synthesisBiochemistry, 1977
- Lectins as probes of chromatin structure. Binding of concanavalin A to purified rat liver chromatin.Journal of Biological Chemistry, 1977
- In vitro Synthesis of Herpes Simplex Virus DNA in Nuclei Isolated from Infected BSC 1 CellsJournal of General Virology, 1977