A Comparison using Quantitative Enzyme Cytochemistry between Leucocyte Alkaline Phosphatase Levels in the Bone Marrow and Blood of the Rat

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Abstract
Leukocyte alkaline phosphatase (LAP) levels were compared in neutrophil polymorphs in [rat] bone marrow and blood, using a quantitative enzyme cytochemical technique. LAP levels were higher in bone marrow than blood, in normal animals and those with experimentally-induced local inflammatory lesions. In the latter group bone marrow and blood LAP levels were higher than in controls. Blood levels rose because of the outpouring of cells with moderately high LAP levels into the blood and marrow levels rose because only cells with very high LAP levels remained. The inverse relationship between neutrophil age and alkaline phosphatase content, previously demonstrated in the peripheral blood of the rat, also existed in the bone marrow.