Radiofrequency Hyperthermia Therapy of Murine Melanoma: A Comparison of Fractionated Versus Single‐Dose Treatments

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Abstract
The effects of single and fractionated doses of radiofrequency hyperthermia were investigated in the treatment of cutaneous murine melanoma. S91 murine melanoma cells were implanted into preformed intradermal blister cavities on the backs of DBA/2J mice. Evaluation of treatment response was undertaken after single and fractionated doses of hyperthermia. A single 60‐second treatment at 46°C did not result in any complete regressions, while 3 weekly 46°C treatments produced a 40% incidence of tumor regression. Higher temperature therapy was associated with improved cure rates. A single treatment for 60 seconds at 50°C resulted in a 25% complete response rate while 3 weekly 50°C treatments resulted in the eradication of 92% of the treated tumors. In those tumors that responded only partially to hyperthermia, fractionated low‐ (46°C) and (50°C) high‐dose regimens resulted in significantly smaller melanomas than single‐treatment schedules at the same temperatures. It is concluded that fractionated hyperthermia is an effective modality in the control of intracutaneous murine melanoma. If other cutaneous malignancies are also sensitive to heat, this may provide a useful nonsurgical means of treating skin cancer.