Antibodies in oligoclonal immunoglobulins in CSF from patients with acute cerebrovascular disease
- 29 January 2009
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 64 (4) , 225-240
- https://doi.org/10.1111/j.1600-0404.1981.tb04402.x
Abstract
Thin-layer polyacrylamide gel isoelectric focusing of CSF and serum, and subsequent immunofixation with viral antigens and structural brain components followed by autoradiography revealed, in 8 of 9 selected patients with oligoclonal CSF IgG and cerebrovascular disease, local synthesis within the CNS of antibodies against 1 or more of the viruses tested: 6 patients against measles, 5 against herpes simplex virus type 1, and 2 against varicella virus. This may reflect a polyclonal B cell activation secondary to brain damage and elaboration of certain structural brain components. None of the patients had local synthesis of antibodies against the other viruses tested (mumps, rubella and cytomegalovirus), or against structural brain components (crude saline, lipid-proteolipid, myelin basic protein extracts from human brain and purified bovine myelin basic protein).Keywords
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