Effects of Acute Fluoride Intoxication on Rats

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Abstract
Summary Young male rats (~200 g) were employed to study the distribution of parenterally administered inert and radiolabeled fluoride. Animals receiving 25 mg of fluoride/kg body weight did not live longer than one hr and the plasma fluoride level reached a concentration of 48 ± 2.1 ppm. Other animals receiving 15 or 20 mg of fluoride/kg had plasma fluoride levels greater than 30 ppm 10 min after the dose but returned to preexperimental levels (~0.10 ppm) by 24 hr. Total and ionic calcium levels in plasma were severely depressed in all animals following the fluoride administrations. The calcium levels at 30 and 60 min did not seem compatible with life although animals receiving 20 mg or less of fluoride/kg survived 24 hr. Radiofluoride concentrations in plasma, muscle, tendon, bone and gastrointestinal tract indicated the relative distribution and retention of the dose as well as the fluoride concentration at 10, 30, and 60 min after the dose was given. Muscle fluoride levels at all dose levels were 5-9 ppm after 10 min. These levels rapidly decreased in animals receiving 15 mg/kg but remained relatively constant for the other animals.

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