Synthesis of stereoisomeric Suc-Tyr-Leu-Val-pNA and their properties as substrate and inhibitor for human spleen fibrinolytic proteinase (SFP).

1 January 1981

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 29 (5) , 1483-1486
https://doi.org/10.1248/cpb.29.1483

Abstract

Stereoisomeric analogues of Suc-Tyr-Leu-Val-pNA were synthesized in the conventional manner and their properties as the substrate and/or the inhibitor against human spleen fibrinolytic proteinase (SFP) were tested. Suc-D-Tyr-L-Leu-L-Val-pNA (II) was hydrolyzed to release p-nitroaniline with K_eat/K_m value (3700), whereas K_eat/K_m value of Suc-L-Tyr-L-Leu-L-Val-pNA (I) was 22647. Suc-L-Tyr-D-Leu-D-Val-pNA (III) inhibited the hydrolytic activity of SFP towards both the peptide (I) and fibrin.

Keywords

SFP
SUC TYR LEU
VAL PNA

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