Suppressive Effect of Iron on in vitro Lymphocyte Function: Formation of Iron Polymers as a Possible Explanation

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Abstract
The evidence presented here indicates that ferric citrate inhibits both the phytohemagglutinin-induced lymphocyte proliferation and the formation of E rosettes by T lymphocytes. These inhibitory effects are only observed in the presence of ferric citrate with a metal to ligand molar ratio of (1:1) but not with ferric citrate (1:20) or sodium citrate. Since ferric citrate (1:1) at a physiological pH tends to hydrolyze and polymerize, we suggest that the inhibitory effect is mediated by the formation of iron polymers.

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