FACTORS AFFECTING THE ACTION OF ANTIGONADOTROPIC SERA IN IMMATURE RATS1

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Abstract
Antigonadotropic sera developed in rabbits and goats are more effective in preventing the gonad-stimulating action of relatively unpurified extracts prepd. from sheep, hog and cow pituitary glands when they and the gonadotropin are injd. separately into immature rats, than when mixed in vitro before injn. Inhibition of the gonad-stimulating action of extracts of sheep and hog pituitary glands was obtained by combined injns. if a sufficient quantity of rabbit or goat antigonadotropic serum was given. With the removal of much of the inert material from sheep pituitary extract, it was found that combined injns. of gonadotropin and antigonadotropic sera were as effective as when administered by separate injns. Gonado-tropins prepd. by aqueous extraction of horse, human and rat pituitary glands, pregnant mares'' serum, and purified prepns. of human pregnancy urine were prevented from acting by combined as well as by separate injns. of serum. These results are explained on the basis of the greater gonadotropic activity of these prepns. per unit of dry wt. as compared to that of sheep, hog and cow pituitary glands.

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