The in-vitro anti-rickettsial activity of macrolides
Open Access
- 1 October 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 38 (4) , 727-731
- https://doi.org/10.1093/jac/38.4.727
Abstract
The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of ≥50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.Keywords
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