CLINICAL EXPERIENCES WITH CORTISONE AND CORTICOTROPIN (ACTH) IN SOME CUTANEOUS DISEASES

Abstract
THE RESULTS obtained with steroid hormones in rheumatoid arthritis, rheumatic fever, "collagen diseases," and hypersensitivity states1 suggested the use of these drugs in treatment of certain related dermatoses. In the following report, first a short survey of the pertinent literature is given, and then our own results in a series of cases of various dermatoses will be discussed. SURVEY OF THE LITERATURE Acute disseminated lupus erythematosus was first shown to be benefited by the use of corticotropin (ACTH) by Grace and Combes.2 In 11 of 14 patients treated with cortisone or corticotropin, Baehr and Soffer, and Soffer, Levitt, and Baehr3 obtained remissions for periods of from one to seven months with cortisone or corticotropin. However, renal changes, anemia, leucopenia, thrombocytopenia, and L. E. cells persisted, and untoward effects were frequent and sometimes serious. Brunsting, Slocumb, and Didcoct4 treated seven patients and obtained subsidence of arthralgia, fever,