Polymorphisms of interleukin-10 and its receptor and lung function in COPD

Open Access

1 March 2007

journal article
Published by European Respiratory Society (ERS) in European Respiratory Journal

Vol. 29 (6) , 1120-1126
https://doi.org/10.1183/09031936.00002907

Abstract

Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the α subunit of its receptor (IL10RA) are associated with changes in, or value of, forced expiratory volume in one second (FEV₁) in smoking-induced chronic obstructive pulmonary disease.

Keywords

LUNG FUNCTION
SMOKING
FORCED EXPIRATORY VOLUME
COPD
CHRONIC OBSTRUCTIVE
PULMONARY DISEASE
ALLELE
SINGLE NUCLEOTIDE POLYMORPHISMS

This publication has 0 references indexed in Scilit: