Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial ParasiteBrugia malayi
- 1 May 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (5) , 3034-3035
- https://doi.org/10.1128/iai.68.5.3034-3035.2000
Abstract
We have investigated the roles of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense againstBrugia malayi. Our data suggest that the lack of either IFN-γ or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.Keywords
This publication has 4 references indexed in Scilit:
- Strategies and tools for the control/elimination of lymphatic filariasis.1997
- Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response.The Journal of Immunology, 1995
- The Regulation of Immunity to Leishmania MajorAnnual Review of Immunology, 1995
- Infectivity and Normal Development of Third Stage Brugia malayi Maintained In vitroJournal of Parasitology, 1994