CONTACT ALLERGY TO COCKLEBUR (XANTHIUM SPINOSUM)

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Abstract
During the last three years I have observed a man aged 68 years who had typical dermatitis venenata in April, two years before I saw him. It started on the face, hands, arms and legs, spreading to a lesser degree over the entire body, gradually diminishing in the fall and winter. It reappeared on the exposed cutaneous areas the following April, with a fairly rapid generalized distribution, being especially severe in the hot months (July to October). When the patient came from his ranch in the Sacramento Valley near Chico to the San Francisco Bay area there was gradual and definite relief. Patch tests with the leaves of all trees, grasses, weeds, shrubs and cultivated flowers on his ranch produced a severe vesicular itching reaction to cocklebur, necessitating the removal of the patch in about four hours and requiring several weeks to heal entirely. A patch test with the moistened

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