Association of p53 arginine polymorphism with skin cancer
- 1 July 2004
- journal article
- Published by Wiley in International Journal of Dermatology
- Vol. 43 (7) , 489-493
- https://doi.org/10.1111/j.1365-4632.2004.02289.x
Abstract
The presence of arginine at codon 72 in p53 protein is proposed to be a genetic risk factor in human papillomavirus (HPV)-related carcinogenesis. To study the prevalence of p53 polymorphism at codon 72 in skin biopsies of epidermodysplasia verruciformis (EV) patients compared to DNA samples from healthy individuals. DNA samples extracted from normal skin and tumor biopsies of 22 Brazilian patients with EV and blood samples from 27 healthy Brazilian individuals were studied for p53 codon 72 polymorphisms using restriction fragment length polymorphism (RFLP) analysis. All EV patients with the malignant form of EV were homozygous for arginine (Arg/Arg) at codon 72 of the p53 gene, in contrast to none with the benign form (P < 0.0001). p53 arginine polymorphism is likely to be associated with the development of skin malignancies in EV patients from Brazil.Keywords
This publication has 25 references indexed in Scilit:
- Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformisNature Genetics, 2002
- Relationship Between p53 Codon 72 Polymorphism and Susceptibility to Sunburn and Skin CancerJournal of Investigative Dermatology, 2002
- p53 codon 72 polymorphism and human papillomavirus associated skin cancerJournal of Clinical Pathology, 2001
- Evidence for a Nonallelic Heterogeneity of Epidermodysplasia Verruciformis with Two Susceptibility Loci Mapped to Chromosome Regions 2p21–p24 and 17q25Journal of Investigative Dermatology, 2000
- A Susceptibility Locus for Epidermodysplasia Verruciformis, an Abnormal Predisposition to Infection with the Oncogenic Human Papillomavirus Type 5, Maps to Chromosome 17qter in a Region Containing a Psoriasis LocusJournal of Investigative Dermatology, 1999
- Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skinArchives of Dermatology, 1995
- High frequency of loss of heterozygosity in actinic keratoses, a usually benign diseaseThe Lancet, 1994
- Is p53 Polymorphism Maintained by Natural Selection?Human Heredity, 1994
- Epidermodysplasia Verruciformis as a Model of Human Papillomavirus-lnduced Genetic Cancers: The Role of Local ImmunosurveillanceThe Lancet Healthy Longevity, 1992
- In vitro expressed HPV 8 E 6 protein does not bind p 53Archiv für die gesamte Virusforschung, 1992