Hyperthyroidism in a Patient with a Pituitary Chromophobe Adenoma

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Abstract
The case is described of a 53-yr-old woman with a 16-yr history of epilepsy and known for 4 yr to have a goiter and a pituitary tumor, the latter being confirmed at autopsy as a chromophobe adenoma. The patient was clinically euthyroid until shortly before her death, when she became overtly thyrotoxic, although repeated radioactive iodine studies had given results in the hyperthyroid range. Her death was due to renal failure with multiple thrombo-embolization of small bowel. The relationship of chromophobe adenomas to TSH production is discussed.