Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

1 August 1977

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 74 (8) , 3466-3470
https://doi.org/10.1073/pnas.74.8.3466

Abstract

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.

Keywords

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