Synthesis of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks.
- 1 January 1994
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 42 (11) , 2241-2250
- https://doi.org/10.1248/cpb.42.2241
Abstract
Synthesis of three cis-trans pairs of N-sulfonylated-2-aziridinemethanols starting from (S)-threonine, (R)-allothreonine, a chiral 2-amino alcohol, or enantiomerically enriched 2, 3-epoxy alcohols is described. A synthetic route to N-tosyl- and N-mesyl-2-aziridinemethanols from (R)- and (S)-serines is also presented.Keywords
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