THE LOCUS OF ACTION OF THE PARATHYROID HORMONE: EXPERIMENTAL STUDIES WITH PARATHYROID EXTRACT ON NORMAL AND NEPHRECTOMIZED RATS 1

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Abstract
Para-thyroid extract produced osteitis fibrosa in rats in 60 hrs.; the bone lesions were the same, whether or not the rats were first nephrectomized. Nephrectomy alone produced bone resorption in rats in 60 hrs.; the bone lesions, however, were qualitatively and quantitatively distinguishable from the lesions produced by parathyroid extract. The lesions produced in nephrectomized rats by parathyroid extract were already present in 20 hrs., whereas lesions produced by nephrectomy had not yet appeared at that time. Evidence is presented that the effect of parathyroid extract on bone tissue in nephrectomized rats is not attributable to the acidity of the extract.