Abstract
Occupation-related asthma and dermatitis among seafood process personnel in a local factory prompted a study of their immune response to antigens in the factory environment, especially those antigens aerosolized during the processing of prawns. A similar clinical syndrome has already been reported (1,2), but the present study examined the nature and extent of the antibody class response to definable inhaled antigens, and assessed the value of this serology as a clinical adjunct in the investigation of hypersensitivity. The effects of intrinsic parameters such as age, gender and atopy, as well as environmental factors such as the extent of antigen exposure and smoking history was also examined in relation to symptoms and the antibody response.

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