An Improved Synthesis of 2′,3′-Dideoxycytidine
- 1 December 1990
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 9 (8) , 1061-1065
- https://doi.org/10.1080/07328319008046062
Abstract
A convenient synthesis of 2′,3′-dideoxycytidine (ddC, 6) from 2′-deoxycytidine (1) has been achieved employing a base-catalyzed elimination of 3′-O−methanesulfonyl group as the key step.Keywords
This publication has 10 references indexed in Scilit:
- A new synthesis of 2′,3′-dideoxycytidineJournal of Heterocyclic Chemistry, 1989
- A Simple and Convenient Method for the Selective N-Acylations of Cytosine NucleosidesNucleosides, Nucleotides and Nucleic Acids, 1989
- A new synthesis of 2′,3′-dideoxynucleosides for aids chemotherapyTetrahedron Letters, 1988
- Synthesis of the dideoxynucleosides "ddC" and "CNT" from glutamic acid, ribonolactone, and pyrimidine basesThe Journal of Organic Chemistry, 1988
- The Synthesis of 2′,3′-Dideoxycytidine and Its 2′-Azido Analogue. Applications of the Deoxygenative [1,2]-Hydride Shift of Sulfonates with Mg(OMe)2–NaBH4Chemistry Letters, 1987
- The Quest for TherapyChemical & Engineering News, 1987
- Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogs of pyrimidine deoxyribonucleosides against retrovirusesJournal of Medicinal Chemistry, 1987
- Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.Proceedings of the National Academy of Sciences, 1986
- Nucleosides. XI. 2',3'-DideoxycytidineThe Journal of Organic Chemistry, 1967
- Purine Nucleosides. XIV. Unsaturated Furanosyl Adenine Nucleosides Prepared via Base-Catalyzed Elimination Reactions of 2'-Deoxyadenosine Derivatives1Journal of the American Chemical Society, 1966