Characterization and mapping of a viable anaemic mutant in the mouse: a new allele,mkvan, at themicrocytic anaemialocus
- 1 February 1988
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 51 (1) , 41-45
- https://doi.org/10.1017/s0016672300023922
Abstract
Summary: A viable anaemic mouse mutant arose in the stock of a mouse fancier and has been characterized haematologically and genetically. Anaemic animals were less viable than normal animals (especially from 0 to 2 weeks of age) and had lower haemoglobin levels, percentage packed-cell volumes, higher red cell counts and lower mean cell volume than normal animals. Peripheral blood films showed a wide range of abnormal cells and extreme microcytosis. Linkage studies showed the mutant to be linked to the chromosome 15 markersNa Caandbt; recombination withCawas 1·37 ± 0·68 % for females and 10·5 ± 7·41 % for males. This position is similar to themicrocytic anaemia, mk, mutant, and crosses between the viable anaemia mutation andmk/mkhomozygotes showed the two to be allelic. Viable anaemia is therefore a second allele at themklocusmkvan; new data give its position on chromosome 15.This publication has 3 references indexed in Scilit:
- Unusual recombination values and the mapping of the lethal miniature in the house mouseGenetics Research, 1972