Modified enzyme immunoassay to detect hepatitis C virus antibodies in oral fluid
- 1 November 1996
- journal article
- other
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 15 (11) , 882-884
- https://doi.org/10.1007/bf01691223
Abstract
Samples of oral fluid collected from 18 patients seropositive for hepatitis C virus (HCV) and 49 seronegative patients were tested for the presence of HCV antibodies with two modified serum-screening kits. The following sensitivities and specificities were obtained: HCV 3.0 assay, 72% and 98%, respectively, and Monolisa anti-HCV assay, 100% and 100%, respectively. The modified Monolisa assay demonstrated a striking concordance between serum and saliva samples. The use of oral fluids offers a convenient and noninvasive method applicable to HCV epidemiological studies and screening of high-risk groups.Keywords
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