SELECTIVE IMMUNOSUPPRESSIVE EFFECTS OF MEASLES-VIRUS INFECTION
- 1 January 1982
- journal article
- research article
- Vol. 47 (1) , 19-26
Abstract
The antibody response to diphtheria toxoid by cultured human tonsil cells was suppressed by measles virus, which productively infected a small percentage of T and B lymphocytes. Infection of cultures spontaneously secreting antibody and Ig (with herpes simplex virus) or measles virus did not result in immunosuppression. Immunosuppression by measles virus may thus be attributed to a selective effect on the inductive phase of the response and infection of Ig-producing B lymphocytes evidently does not alter the ability of these cells to secrete antibody.This publication has 14 references indexed in Scilit:
- Herpes simplex virus depresses antibody production by affecting T-cell functionNature, 1980
- Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosisProceedings of the National Academy of Sciences, 1979
- Activation of measles virus from silently infected human lymphocytes.The Journal of Experimental Medicine, 1978
- Cell-Mediated Immunity during Natural Measles InfectionJournal of Clinical Investigation, 1978
- Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes.The Journal of Experimental Medicine, 1975
- Measles virus receptor on human T lymphocytesNature, 1975
- The effect of measles virus infection on T and B lymphocytes in the mouse. I. Suppression of helper cell activity.1974
- Studies on leukocyte cultures in measlesArchiv für die gesamte Virusforschung, 1974
- A Useful Quantitative Semimicromethod for Viral Plaque AssayExperimental Biology and Medicine, 1973
- The effect of measles on the thymus and other lymphoid tissues.1973