Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
Open Access
- 13 April 1995
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 374 (6523) , 617-622
- https://doi.org/10.1038/374617a0
Abstract
Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.Keywords
This publication has 49 references indexed in Scilit:
- Vertebrate Embryonic Induction: Mesodermal and Neural PatterningScience, 1994
- Processed Vg1 protein is an axial mesoderm inducer in xenopusCell, 1993
- Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.Genes & Development, 1993
- A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryosNature, 1992
- Wnt genesCell, 1992
- Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing centerCell, 1991
- Injected Wnt RNA induces a complete body axis in Xenopus embryosCell, 1991
- Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryosCell, 1991
- Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresCell, 1990
- Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axisCell, 1989