HLA PHENOTYPE AND INSULIN ANTIBODY-PRODUCTION

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 57  (2) , 443-448
Abstract
HLA phenotypes were determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 mo. after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7, and this, in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia hemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a nonspecific abnormality of immunity.