Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

1 January 1980

journal article
research article
Published by Springer Nature in Nature

Vol. 283 (5744) , 264-267
https://doi.org/10.1038/283264a0

Abstract

The appearance of acetylcholinesterase (AChE) at newly formed nerve–muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists, but AChE does not accumulate at these synapses. The important component of transmission seems to be muscle activity. Treatment with dibutyryl cyclic GMP mimics muscle activity, directly inducing synaptic AChE appearance.

Keywords

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