IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

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Abstract
Complement activity of 421 sera from 330 children was determined. Complement activity was not influenced by antecedent illness. Low complement titers were found in approximately 25% of 75 normal children during intercurrent illness. Approximately 25% of 29 patients with active rheumatic fever had low complement titers. No evidence was obtained to indicate that complement activity is a factor in hereditary susceptibility to rheumatic fever.