Discoid Lupus Erythematosus Treated with Plaguenil

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Abstract
Since Page1 first introduced the use of quinacrine for the treatment of lupus erythematosus, interest in and popularity of this form of therapy have remained unabated. Enthusiasm about a drug generally wanes after its use for some time, and quinacrine is no exception to this rule. The use of antimalarials for lupus erythematosus, however, is not ebbing, because newer and more effective ones are being provided. The similarity of the members of the group has made it easier for the later arrivals to gain an easier acceptance. Practitioners were quick to find chloroquine a safer drug than quinacrine, and besides more effective clinically. Plaquenil (7-chloro-4-[4-(N-ethyl-N-β-hydroxy-ethylamino)-1-methylbutylamino]quinoline) is still less toxic than its immediate predecessor, and preliminary trials seem to show it is at least as effective in lupus erythematosus. Since no method or drug yet devised is capable of clearing or

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