A Comparison of Two Nonclassical Models for Oxygen Consumption in Brain and Liver Tissue

Publisher Website
Google Scholar
Abstract
Warburg-type experiments using tissue slices demonstrate non-classical chemical reaction kinetics [7]. Longmuir et al. [8] found that a Michaelis-Menten kinetic model more accurately. described experimental data from several different tissues. Brain tissue oxygen consumption was not significantly different from classical zero-order reaction kinetics, whereas liver tissue exhibited the most substantial deviation from the classical model. More recently, Buerk and Longmuir [2] have shown that oxygen consumption does not follow simple zero-order kinetics in either brain or liver tissue. The experimentally measured steady-state pO2 profiles from this study have been compared with nonclassical models for oxygen consumption.