Preparation of Chiral β-Hydroxyketones by Aldol-type Condensation of Chiralp-Tolylsulfinylmethyl Ketones
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (07) , 582-584
- https://doi.org/10.1055/s-1986-31715
Abstract
Chiral ß-hydroxyketones 7 with fair e.e. were prepared by treating newly prepared optically pure p-tolylsulfinylmethyl ketones 4 with t-butyl-magnesium bromide and aldehydes 5 followed by desulfurization with aluminium amalgam.Keywords
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