SELECTIVE CLEAVAGE OF N-t-BUTOXYCARBONYL PROTECTING GROUP

Abstract
The selective cleavage of BOC-peptide-OBut was investigated by the use of 85% formic acid, and it was found that BOC-peptide-OBut gave H-peptide-OBut in good yield by this procedure. This method was also applied to investigation of the selectivity of di-t-butyl esters of dibasic amino acids and N-deprotection of peptides containing these amino acids.