Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein
- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Cell Research
- Vol. 15 (1) , 19-23
- https://doi.org/10.1038/sj.cr.7290258
Abstract
Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demonstrated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention.Keywords
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