Effects of isoproterenol on chemical carcinogenesis with DMBA in mouse salivary glands

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Abstract
Histopathological studies were conducted on experimental carcinogenesis in mouse salivary glands using D,L-isoproterenol hydrochloride (isoproterenol) and 9,10-dimethyl-1,2-benzanthracene (DMBA). DMBA was administered once at 1 mg/0.02 ml in olive oil to the salivary glands, and isoproterenol was injected i.p. at 1 mg/0.05 ml saline solution 3 times a week for 2 wk at different periods during the oncogenic process. Salivary glands treated with carcinogen showed a relatively constant sequence of changes and developed epithelial and mesenchymal tumors irrespective of isoproterenol administration. Isoproterenol did not influence the development of another type of tumor; however, it did retard the oncogenic processes.