EFFECT OF RENAL-FUNCTION IMPAIRMENT ON IPROPLATIN PHARMACOKINETICS AND RELATION TO TOXICITY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (11) , 5936-5938
Abstract
The pharmacokinetics of iproplatin, a quadrivalent second-generation platinum complex the dose-limiting toxicity of which is myelosuppression, was studied in patients with different degrees of renal function impairment. The drug was administered in a 30-min i.v. infusion. The plasma decay of iproplatin was biphasic, with an overall median terminal phase half-life of 3.16 .+-. 2.6 (SD) h. The overall mean volume of distribution (Vss) was 39.9 .+-. 25.0 liters, with a total body clearance of 14.25 .+-. 3.99 liters/h. The total body clearance of iproplatin showed a linear correlation, with renal function measured as creatinine clearance. The toxicity of the drug, expressed as percentage of reduction in platelet count, correlated linearly with the area under the concentration .times. time curve.