D-amphetamine disaggregates brain polysomes via a dopaminergic mechanism.
- 1 March 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (3) , 834-836
- https://doi.org/10.1073/pnas.72.3.834
Abstract
Brain polysomes are disaggregated in rats given moderate to large doses of d-amphetamine sulfate; this response is rapid in onset, lasts for at least 4-6 hr, and varies with the age of the animal. Pretreatment with a dopamine receptor blocking agent, haloperidol or pimozide, blocks the amphetamine-induced disaggregation.Keywords
This publication has 20 references indexed in Scilit:
- Antagonism of acute amphetamine intoxication by haloperidol and propranolol*1Toxicology and Applied Pharmacology, 1974
- Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine‐induced glycogenolysis in the brainBritish Journal of Pharmacology, 1973
- Studies on the relation of chemical structure to glycogenolytic activity in the brainEuropean Journal of Pharmacology, 1972
- Dopamine: Mediator of Brain Polysome Disaggregation after L-DopaScience, 1972
- Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brainEuropean Journal of Pharmacology, 1971
- Diethyldithiocarbamate and amphetamine stereotype behaviourJournal of Pharmacy and Pharmacology, 1966
- EFFECT OF DRUGS ON UPTAKE RELEASE AND METABOLISM OF H3-NOREPINEPHRINE IN RAT BRAIN1965
- EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE1965
- Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse BrainActa Pharmacologica et Toxicologica, 1963
- CHANGES IN SENSITIVITY TO AMPHETAMINE IN RATS WITH CHRONIC BRAIN LESIONS1961