Cell distribution in chimaeric mouse embryos before implantation

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Abstract
Eight-cell mouse embryos labelled by prior cultivation in the presence of tritiated thymidine were aggregated with unlabelled 8-cell stages, and allowed to develop in vitro for two further cell divisions. Autoradiographic analysis of the resulting embryos showed that little or no mixing of the two cell populations took place during this period, either in the trophoblast or in the inner cell mass.