Ether Lipid Ester Derivatives of Cidofovir Inhibit Polyomavirus BK Replication In Vitro
- 1 April 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (4) , 1564-1566
- https://doi.org/10.1128/aac.50.4.1564-1566.2006
Abstract
Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index.Keywords
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