5α-Reductase Type 1 Immunostaining is Enhanced in Some Prostate Cancers Compared With Benign Prostatic Hyperplasia Epithelium
- 1 November 2003
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 170 (5) , 2019-2025
- https://doi.org/10.1097/01.ju.0000091804.20183.81
Abstract
Purpose: In the prostate testosterone is converted to the more potent androgen dihydrotestosterone by the enzymes 5α-reductase (5αR) types 1 (5αR1) and 2 (5αR2). Since 5αR2 is the dominant ...Keywords
This publication has 18 references indexed in Scilit:
- The Future of Prostate Cancer PreventionAnnals of the New York Academy of Sciences, 2001
- Differences in steroid 5α-reductase iso-enzymes expression between normal and pathological human prostate tissueThe Journal of Steroid Biochemistry and Molecular Biology, 1999
- SELECTIVITY OF FINASTERIDE AS AN IN VIVO INHIBITOR OF 5 alpha-REDUCTASE ISOZYME ENZYMATIC ACTIVITY IN THE HUMAN PROSTATEJournal of Urology, 1999
- The localisation and expression of 5 alpha-reductase types I and II mRNAs in human hyperplastic prostate and in prostate primary culturesJournal of Endocrinology, 1998
- Characterization of 5α-reductase gene expression in stroma and epithelium of human prostateThe Journal of Steroid Biochemistry and Molecular Biology, 1996
- Immunocytochemical Evidence for Differential Subcellular Localization of 5α-Reductase Isoenzymes in Human TissuesCells Tissues Organs, 1996
- Expression and Regulation of Steroid 5α-Reductase 2 in Prostate DiseaseJournal of Urology, 1994
- Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.Journal of Clinical Investigation, 1993
- Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasiaJournal of Clinical Endocrinology & Metabolism, 1992
- Kinetic Parameters of 5α-Reductase Activity in Stroma and Epithelium of Normal, Hyperplastic, and Carcinomatous Human Prostates*Journal of Clinical Endocrinology & Metabolism, 1988