THE RESPONSE OF OBESE SUBJECTS TO CONTINUOUS INFUSION OF HUMAN PANCREATIC GROWTH HORMONE‐RELEASING FACTOR 1–44

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Abstract
SUMMARY: The growth hormone (GH) response of seven obese subjects to a 4 h continuous infusion of human pancreatic GH‐releasing factor, 0·3 μg/kg/h, has been compared with that obtained in seven sex and age matched controls. The pattern of response was normal in the obese but peak GH levels (mean ± SEM: 13·8 ± 1·9 compared to 30·9 ± 4·7 mU/l, P < 0·01) and integrated GH levels (mean ± SEM: 27·1 ± 3·6 compared to 62·0 ± 9·7 mU/l/h, P < 0·01) were reduced in obese subjects. There was a negative correlation between the integrated GH response and the percentage ideal body weight (r=−0·80, P < 0·05), but no significant correlation with somatomedin‐C levels (r=+ 0·72; P= 0·07). Obese subjects have an impaired GH response to infusion of GH‐releasing factor which is not related to negative feedback by somatomedins.